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Joachim Roth Selected Research

macrophage stimulatory lipopeptide 2

6/2012Fever induction by systemic stimulation with macrophage-activating lipopeptide-2 depends upon TLR2 but not CD36.
7/2010Peripheral and central cyclooxygenase (COX) products may contribute to the manifestation of brain-controlled sickness responses during localized inflammation induced by macrophage-activating lipopeptide-2 (MALP-2).
4/2008Macrophage-activating lipopeptide-2 (MALP-2) induces a localized inflammatory response in rats resulting in activation of brain sites implicated in fever.
1/2006Pyrexia, anorexia, adipsia, and depressed motor activity in rats during systemic inflammation induced by the Toll-like receptors-2 and -6 agonists MALP-2 and FSL-1.

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Joachim Roth Research Topics

Disease

35Fever (Fevers)
01/2022 - 01/2002
26Inflammation (Inflammations)
01/2022 - 04/2003
6Anorexia
01/2022 - 01/2006
6Hypothermia
07/2014 - 02/2002
4Infections
01/2017 - 01/2009
3Necrosis
01/2022 - 01/2002
3Neuroinflammatory Diseases
01/2021 - 08/2015
3Encephalitis (Encephalitis, Rasmussen)
10/2019 - 12/2011
2Pain (Aches)
04/2021 - 09/2018
2Neoplasms (Cancer)
01/2019 - 01/2018
2Lethargy
06/2013 - 06/2011
2Hyperthermia
05/2009 - 10/2003
1Hyperalgesia
07/2022
1Neuralgia (Stump Neuralgia)
07/2022
1Embolic Stroke
07/2021
1Stroke (Strokes)
07/2021
1Thrombosis (Thrombus)
07/2021
1Middle Cerebral Artery Infarction (Middle Cerebral Artery Syndrome)
07/2021
1Sepsis (Septicemia)
06/2021
1Chronic Disease (Chronic Diseases)
01/2020
1Obesity
01/2020
1Systemic Inflammatory Response Syndrome (Sepsis Syndrome)
01/2018
1Hydrocephalus (Hydrocephaly)
06/2016
1Depressive Disorder (Melancholia)
08/2015

Drug/Important Bio-Agent (IBA)

26LipopolysaccharidesIBA
01/2022 - 01/2002
20Interleukin-6 (Interleukin 6)IBA
01/2020 - 01/2002
18CytokinesIBA
01/2022 - 01/2002
9ProstaglandinsIBA
11/2017 - 01/2002
7Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
01/2018 - 04/2003
7Diclofenac (SR 38)FDA LinkGeneric
06/2015 - 01/2002
6Dinoprostone (PGE2)FDA Link
06/2015 - 10/2003
6Prostaglandin-Endoperoxide Synthases (Cyclooxygenase)IBA
06/2015 - 04/2003
5InterleukinsIBA
01/2022 - 06/2011
5PyrogensIBA
05/2009 - 06/2002
4Transcription Factors (Transcription Factor)IBA
11/2017 - 01/2004
4macrophage stimulatory lipopeptide 2IBA
06/2012 - 01/2006
3Proteins (Proteins, Gene)FDA Link
01/2021 - 01/2019
3Nitric Oxide (Nitrogen Monoxide)FDA Link
01/2019 - 02/2002
3CCAAT-Enhancer-Binding Protein-betaIBA
11/2017 - 02/2011
3AntipyreticsIBA
10/2014 - 09/2006
3Interleukin-10 (Interleukin 10)IBA
07/2014 - 02/2013
2Messenger RNA (mRNA)IBA
01/2022 - 12/2011
2HMGB1 Protein (HMG1)IBA
06/2021 - 01/2020
2Pathogen-Associated Molecular Pattern MoleculesIBA
01/2020 - 04/2008
2Toll-Like Receptors (Toll-Like Receptor)IBA
10/2014 - 04/2008
2LeptinIBA
02/2014 - 05/2007
2Poly I-CIBA
11/2012 - 06/2007
2EnzymesIBA
12/2011 - 05/2009
2Prostaglandins EIBA
07/2010 - 08/2005
2Meloxicam (Mobic)FDA LinkGeneric
07/2010 - 01/2002
2Pharmaceutical PreparationsIBA
05/2009 - 04/2009
2Carrier Proteins (Binding Protein)IBA
07/2007 - 04/2003
2Nitric Oxide Synthase (NO Synthase)IBA
01/2007 - 02/2002
2Hydrocortisone (Cortisol)FDA LinkGeneric
10/2004 - 01/2002
1Pregabalin (Lyrica)FDA Link
07/2022
1Gabapentin (Neurontin)FDA LinkGeneric
07/2022
1HMGB ProteinsIBA
06/2021
1Monocarboxylic Acid TransportersIBA
01/2021
12-cyano-3-(1-phenylindol-3-yl)acrylateIBA
01/2021
1Pyruvic Acid (Pyruvate)IBA
01/2021
1AdipokinesIBA
01/2020
1BiglycanIBA
01/2020
1LipidsIBA
10/2019
1Phospholipids (Phosphatides)FDA LinkGeneric
10/2019
1Phosphatidylcholines (Phosphatidylcholine)IBA
10/2019
1PC 16IBA
10/2019
1Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA
10/2019
1Ethanolamine (Colamine)IBA
10/2019
1Oxygen (Dioxygen)IBA
01/2019
1CytoglobinIBA
01/2019
1Biomarkers (Surrogate Marker)IBA
09/2018
1Deubiquitinating EnzymesIBA
01/2018
1C-Reactive ProteinIBA
01/2018
1Fluorescent Dyes (Fluorescent Probes)IBA
11/2017
1Small Interfering RNA (siRNA)IBA
11/2017
1KininsIBA
11/2017
1icatibantIBA
11/2017
1Captopril (Capoten)FDA LinkGeneric
11/2017
1BradykininIBA
11/2017
1leukocyte endogenous mediatorIBA
01/2017
1Tryptophan (L-Tryptophan)FDA Link
08/2015
1Serotonin (5 Hydroxytryptamine)IBA
08/2015
1Prostaglandin D2IBA
06/2015
1Local AnestheticsIBA
06/2015
1Complement System Proteins (Complement)IBA
10/2014
1CCR5 Receptors (CCR5 Receptor)IBA
11/2013
1ChemokinesIBA
11/2013
1alpha- cyano- (3,4- dihydroxy)- N- benzylcinnamideIBA
08/2013
1Pyr(1)- apelin 13IBA
06/2013
1Cyclooxygenase 2 (Cyclooxygenase-2)IBA
12/2011
1parthenolideIBA
12/2011
1interleukin-1beta-converting enzyme inhibitorIBA
06/2011
1Cyclooxygenase 2 Inhibitors (COX-2 Inhibitors)IBA
07/2010
1Bosentan (Tracleer)FDA Link
05/2009

Therapy/Procedure

5Injections
11/2017 - 06/2004
5Intraperitoneal Injections
06/2013 - 02/2002
2Intravenous Injections
01/2020 - 10/2004
1Microbubbles
07/2021
1Intravenous Administration
12/2016
1Ventriculoperitoneal Shunt
06/2016